Listeria monocytogenes: A Tale of Food-Borne Pathogen
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Abstract
Listeria monocytogenes is one of the major foods borne pathogen that is found in soil, water and animal faeces which causes the disease known as listeriosis. The pathogen mainly affects the newborns, pregnant women, elderly age people, and immunocompromised host. It mainly enters in the gut of humans through the intake of raw vegetables, unwashed foods, uncooked or half cooked food. It is difficult to recognize the bacteria as it does not bring immediate change in the food color and food taste. This review aims to highlight the mechanism of infection of the bacteria, its special characteristics, symptoms of the disease, pathogenesis and treatment prevention.
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Grigore-Gurgu L, Bucur FI, Mihalache OA, Nicolau AI. Comprehensive review on the biocontrol of Listeria monocytogenes in food products. Foods. 2024;13(5):734. Available from: https://doi.org/10.3390/foods13050734
Bento D, Bomar PA. Listeria monocytogenes. StatPearls Publishing; 2024. Available from: https://pubmed.ncbi.nlm.nih.gov/30521259/
Farber JM, Peterkin PI. Listeria monocytogenes, a food-borne pathogen. Microbiol Rev. 1991;55(3):476–511. Available from: https://doi.org/10.1128/mr.55.3.476-511.1991
Osek J, Wieczorek K. Why does Listeria monocytogenes survive in food and food-production environments? J Vet Res. 2023;67(4):537–544. Available from: https://doi.org/10.2478/jvetres-2023-0068
Desai AN, Anyoha A, Madoff LC, Lassmann B. Changing epidemiology of Listeria monocytogenes outbreaks, sporadic cases, and recalls globally: a review of ProMED reports from 1996 to 2018. Int J Infect Dis. 2019;84:48–53. Available from: https://research.amanote.com/publication/qJ8g3nMBKQvf0BhiLnPG/changing-epidemiology-of-listeria-monocytogenes-outbreaks-sporadic-cases-and-recalls
Silva A, Silva V, Gomes JP, Coelho A, Batista R, Saraiva C, et al. Listeria monocytogenes from food products and food-associated environments: antimicrobial resistance, genetic clustering and biofilm insights. Antibiotics. 2024;13(5):447. Available from: https://www.oasisbr.ibict.br/vufind/Record/RCAP_7d3d36b1b012da63029deb96d9756923
Fleming DW, Cochi SL, MacDonald KL, Brondum J, Hayes PS, Plikaytis BD, et al. Pasteurized milk as a vehicle of infection in an outbreak of listeriosis. N Engl J Med. 1985;312:404–407. Available from: https://doi.org/10.1056/nejm198502143120704
de las Heras A, Cain RJ, Bielecka MK, Vazquez-Boland JA. Regulation of Listeria virulence: PrfA master and commander. Curr Opin Microbiol. 2011;14:118–127. Available from: https://doi.org/10.1016/j.mib.2011.01.005
Lecuit M. Human listeriosis and animal models. Microbes Infect. 2007;9:1216–1225. Available from: https://doi.org/10.1016/j.micinf.2007.05.009
Gaillard JL, Berche P, Frehel C, Gouin E, Cossart P. Entry of Listeria monocytogenes into cells is mediated by internalin. Cell. 1991;65:1127–1141. Available from: https://doi.org/10.1016/0092-8674(91)90009-n
Vazquez-Boland JA, Dominguez-Bernal G, Gonzalez-Zorn B, Kreft J, Goebel W. Pathogenicity islands and virulence evolution in Listeria. Microbes Infect. 2001;3:571–584. Available from: https://doi.org/10.1016/s1286-4579(01)01413-7
Freitag NE, Port GC, Miner MD. Listeria monocytogenes: from saprophyte to intracellular pathogen. Nat Rev Microbiol. 2009;7(9):623–628. Available from: https://doi.org/10.1038/nrmicro2171
Robbins JR, Skrzypczynska KM, Zeldovich VB, Kapidzic M, Bakardjiev AI, Schneider DS. Placental syncytiotrophoblast constitutes a major barrier to vertical transmission of Listeria monocytogenes. PLoS Pathog. 2010;6(1):e1000732. Available from: https://doi.org/10.1371/journal.ppat.1000732
Lecuit M, Nelson DM, Smith SD, Khun H, Huerre M, Vacher-Lavenu MC, et al. Targeting and crossing of the human maternofetal barrier by Listeria monocytogenes. Proc Natl Acad Sci USA. 2004;101(16):6152–6157. Available from: https://research.pasteur.fr/en/publication/targeting-and-crossing-of-the-human-maternofetal-barrier-by-listeria-monocytogenes-role-of-internalin-interaction-with-trophoblast-e-cadherin/
Vigliani MB, Bakardjiev AI. Intracellular organisms as placental invaders. Fetal Matern Med Rev. 2014;25(3–4):332–338. Available from: https://doi.org/10.1017/S0965539515000066
Correia de Sá A, Casanova D, Ferreira AL, Fernandes C, Cotter J. Listeriosis in pregnancy: a rare but high-risk infection. Cureus. 2023;15(10):e47748. Available from: https://www.cureus.com/articles/200788-listeriosis-in-pregnancy-a-rare-but-high-risk-infection#!/
Rowe JH, Ertelt JM, Aguilera MN, Farrar MA, Way SS. Foxp3(+) regulatory T cell expansion required for sustaining pregnancy compromises host defense. Cell Host Microbe. 2011;10(1):54–64. Available from: https://doi.org/10.1016/j.chom.2011.06.005
Rowe JH, Ertelt JM, Xin L, Way SS. Listeria monocytogenes cytoplasmic entry induces fetal wastage. PLoS Pathog. 2012;8(8):e1002873. Available from: https://doi.org/10.1371/journal.ppat.1002873
Chaturvedi V, Ertelt JM, Jiang TT, Kinder JM, Xin L, Owens KJ, et al. CXCR3 blockade protects against Listeria monocytogenes-induced fetal wastage. J Clin Invest. 2015;125(4):1713–1725. Available from: https://doi.org/10.1172/jci78578
Krishnan L, Pejcic-Karapetrovic B, Gurnani K, Zafer A, Sad S. Pregnancy does not deter development of protective CD8+ T-cell responses. Am J Reprod Immunol. 2010;63(1):54–65. Available from: https://doi.org/10.1111/j.1600-0897.2009.00766.x
Krishnan L, Pejcic-Karapetrovic B, Gurnani K, Zafer A, Sad S. Pregnancy does not deter the development of a potent maternal protective CD8+ T-cell immune response against Listeria monocytogenes. Am J Reprod Immunol. 2010;63(1):54–65. Available from: https://doi.org/10.1111/j.1600-0897.2009.00766.x
Tachibana M, Hashino M, Nishida T, Shimizu T, Watarai M. Protective role of heme oxygenase-1 in Listeria monocytogenes-induced abortion. PLoS One. 2011;6(9):e25046. Available from: https://doi.org/10.1371/journal.pone.0025046
Qiu X, Zhu L, Pollard JW. Colony-stimulating factor-1-dependent macrophage functions regulate maternal immune responses against Listeria monocytogenes during early gestation. Infect Immun. 2009;77(1):85–97. Available from: https://doi.org/10.1128/iai.01022-08
Walker SJ, Archer P, Banks JG. Growth of Listeria monocytogenes at refrigeration temperatures. J Appl Bacteriol. 1990;68:157–162. Available from: https://doi.org/10.1111/j.1365-2672.1990.tb02561.x
Bucur FI, Grigore-Gurgu L, Crauwels P, Riedel CU, Nicolau AI. Resistance of Listeria monocytogenes to stress conditions encountered in food and food processing environments. Front Microbiol. 2018;9:2700. Available from: https://doi.org/10.3389/fmicb.2018.02700
Cotter PD, Hill C. Surviving the acid test: responses of gram-positive bacteria to low pH. Microbiol Mol Biol Rev. 2003;67(3):429–453. Available from: https://doi.org/10.1128/mmbr.67.3.429-453.2003
Soares CA, Knuckley B. Mechanistic studies of the agmatine deiminase from Listeria monocytogenes. Biochem J. 2016;473:1553–1561. Available from: https://doi.org/10.1042/bcj20160221
Byun KH, Kim HJ. Survival strategies of Listeria monocytogenes under environmental stress: biofilm formation and stress responses. Food Sci Biotechnol. 2023;32(12):1631–1651. Available from: https://doi.org/10.1007/s10068-023-01427-6
Yang Y, Kong X, Niu B, Yang J, Chen Q. Differences in biofilm formation of Listeria monocytogenes and their effects on virulence and drug resistance. Foods. 2024;13(7):1076. Available from: https://doi.org/10.3390/foods13071076
West KHJ, Ma SV, Pensinger DA, Tucholski T, Tiambeng TN, Eisenbraun EL, et al. Characterization of an autoinducing peptide signal in quorum sensing and biofilm formation in Listeria monocytogenes. Biochemistry. 2023;62(19):2878–2892. Available from: https://doi.org/10.1021/acs.biochem.3c00373
Finn L, Onyeaka H, O’Neill S. Listeria monocytogenes biofilms in food-associated environments: a persistent enigma. Foods. 2023;12(18):3339. Available from: https://doi.org/10.3390/foods12183339
Miller MB, Bassler BL. Quorum sensing in bacteria. Annu Rev Microbiol. 2001;55:165–199. Available from: https://doi.org/10.1146/annurev.micro.55.1.165
Baquero F, Lanza VF, Duval M, Coque TM. Ecogenetics of antibiotic resistance in Listeria monocytogenes. Mol Microbiol. 2020;113(3):570–579. Available from: https://doi.org/10.1111/mmi.14454
Bäckman A, Lantz P, Rådström P, Olcén P. Evaluation of an extended diagnostic PCR assay for detection of bacterial meningitis. Mol Cell Probes. 1999;13:49–60. Available from: https://doi.org/10.1006/mcpr.1998.0218
Song C, Wang B, Wang Y, Liu J, Wang D. Detection of Listeria monocytogenes using the Proofman-LMTIA assay. Molecules. 2023;28(14):5457. Available from: https://doi.org/10.3390/molecules28145457
Fernández-Blanco A, Hernández-Pérez M, Moreno-Trigos Y, García-Hernández J. Development of optical label-free biosensor method for detection of Listeria monocytogenes. Sensors (Basel). 2023;23(12):5570. Available from: https://doi.org/10.3390/s23125570
Churchill RL, Lee H, Hall JC. Detection of Listeria monocytogenes and listeriolysin O in food. J Microbiol Methods. 2006;64(2):141–170. Available from: https://doi.org/10.1016/j.mimet.2005.10.007
Ma L, Yi J, Wisuthiphaet N, Earles M, Nitin N. Accelerating detection of bacteria in food using artificial intelligence and optical imaging. Appl Environ Microbiol. 2023;89(1):e0182822. Available from: https://aifs.ucdavis.edu/news/accelerating-the-detection-of-bacteria-in-food-using-ai-and-optical-imaging
Hameed S, Xie L, Ying Y. Conventional and emerging detection techniques for pathogenic bacteria in food science: a review. Trends Food Sci Technol. 2018;81:61–73. Available from: https://www.sciencedirect.com/science/article/abs/pii/S0924224417307689
Tanaka T, Kogiso A, Maeda Y, Matsunaga T. Colony fingerprinting: a novel method for discrimination of food-contaminating microorganisms based on bioimage informatics. In: Proc IEEE Int Symp Circuits Syst. 2019. Available from: https://ieeexplore.ieee.org/document/8702644