Acrometastasis as fi rst sign of adenocarcinoma of the lung

Main Article Content

Zuhat URAKÇI*
Senar EBİNÇ
Mehmet KÜÇÜKÖNER
Suat MORKUZU
Özge YAMAN COŞKUN
Zeynep ORUÇ
Yasin SEZGİN
Erkan BİLEN
Oğur KARHAN
Nadiye AKDENİZ
Muhammet Ali KAPLAN
Abdurrahman IŞIKDOĞAN

Abstract

Lung cancer is a major cause of morbidity and mortality worldwide. Metastasis can be seen in many organs in advanced-stage disease. Acral metastasis rate in cancer is quite low. However, because of the direct opening of the arterial circulation, the risk of acral metastasis stem from lung cancer is higher than any other cancers. Although the mechanism is not known exactly, acral metastases occur in dominant extremities. Here, we present a case with lung adenocarcinoma metastasis of the left hand in the second phalanx. We presented this case which is rarely seen in the literature to emphasize acral metastases.

Article Details

URAKÇI, Z., EBİNÇ, S., KÜÇÜKÖNER, M., MORKUZU, S., COŞKUN, Özge Y., ORUÇ, Z., … IŞIKDOĞAN, A. (2020). Acrometastasis as fi rst sign of adenocarcinoma of the lung. Archives of Case Reports, 4(1), 007–009. https://doi.org/10.29328/journal.acr.1001029
Case Reports

Copyright (c) 2020 URAKÇI Z, et al.

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

The Archives of Case Reports is committed in making it easier for people to share and build upon the work of others while maintaining consistency with the rules of copyright. In order to use the Open Access paradigm to the maximum extent in true terms as free of charge online access along with usage right, we grant usage rights through the use of specific Creative Commons license.

License: Copyright © 2017 - 2025 | Creative Commons License Open Access by Archives of Case Reports is licensed under a Creative Commons Attribution 4.0 International License. Based on a work at Heighten Science Publications Inc.

With this license, the authors are allowed that after publishing with the journal, they can share their research by posting a free draft copy of their article to any repository or website.

Compliance 'CC BY' license helps in:

Permission to read and download
Permission to display in a repository
Permission to translate
Commercial uses of manuscript

'CC' stands for Creative Commons license. 'BY' symbolizes that users have provided attribution to the creator that the published manuscripts can be used or shared. This license allows for redistribution, commercial and non-commercial, as long as it is passed along unchanged and in whole, with credit to the author.

Please take in notification that Creative Commons user licenses are non-revocable. We recommend authors to check if their funding body requires a specific license. 

Brambilla E, Travis WD. Lung cancer. In: World Cancer Report, Stewart BW, Wild CP (Eds), World Health Organization, Lyon 2014.

Siegel RL, Miller KD, Jemal A. Cancer statistics, 2019. CA Cancer J Clin. 2019; 69: 7-34. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/30620402

Kocher F1, Hilbe W2, Seeber A3, Pircher A4, Schmid Tm et al. Longitudinal analysis of 2293 NSCLC patients: a comprehensive study from the TYROL registry. Lung Cancer. 2015; 87: 193-200. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/25564398

Hyde L, Hyde CI. Clinical manifestations of lung cancer. Chest. 1974; 65: 299-306. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/4813837

Chute CG, Greenberg ER, Baron J, Korson R, Baker J, et al. Presenting conditions of 1539 population-based lung cancer patients by cell type and stage in New Hampshire and Vermont. Cancer. 1985; 56: 2107-2111. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/2992757

Kerin R. The hand in metastatic disease. J Hand Surg Am. 1987; 12: 77–83. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/3543107

Tolo ET, Cooney WP, Wenger DE. Renal cell carcinoma with metastases to the triquetrum: case report. J Hand Surg Am. 2002; 27: 876–881. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/12239679

Kerin R. Metastatic tumors of the hand. J Bone Joint Surg Am. 1958; 40-A: 263–277. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/13539054

Guttmann G, Stein I. Metastatic tumor of the thumb from adenocarcinoma of the colon. Int Surg. 1968; 49: 217–221. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/5672886

Gallagher B, Yousef G, Bishop L. Subungual metastasis from a rectal primary: case report and review of the literature. Dermatol Surg. 2006; 32: 592–595. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/16681673

Hillers TK, Sauve MD, Guyatt GH. Analysis of published studies on the detection of extrathoracic metastases in patients presumed to have operable non-small cell lung cancer. Thorax. 1994; 49: 14-19. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/8153934

Oliver TW Jr, Bernardino ME, Miller JI, Mansour K, Greene D, et al. Isolated adrenal masses in nonsmall-cell bronchogenic carcinoma. Radiology. 1984; 153: 217218. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/6473783

Mujoomdar A1, Austin JH, Malhotra R, Powell CA, Pearson GD,, et al. Clinical predictors of metastatic disease to the brain from non-small cell lung carcinoma: primary tumor size, cell type, and lymph node metastases. Radiology. 2007; 242: 882-888. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/17229875

De Wever W, Vankan Y, Stroobants S, Verschakelen J. Detection of extrapulmonary lesions with integrated PET/CT in the staging of lung cancer. Eur Respir J. 2007; 29: 995-1002. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/17331966

Hiraki A, Ueoka H, Takata I, Gemba K, Bessho A, et al. Hypercalcemia-leukocytosis syndrome associated with lung cancer. Lung Cancer. 2004; 43: 301-307. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/15165088

Kerin R. Metastatic tumors of the hand. A review of the literature. J Bone Joint Surg Am. 1983; 65: 1331–1335. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/6654944

Handley WS. Cancer of the Breast and its Operative Treatment. London: John Murray; 1906.

Asencio G, Hafdi C, Pujol H, Allieu Y. Osseous metastases in the hand. A general review of three cases. Ann Chir Main. 1982; 1: 137–145. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/6927376

Healey JH, Turnbull AD, Miedema B, Lane JM. Acrometastases. A study of twenty-nine patients with osseous involvement of the hands and feet. J Bone Joint Surg Am. 1986; 68: 743–746. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/3459730

Joll CA. Metastatic tumors of bone. Br J Surg. 1923; 11: 38–72.

Amadio PC, Lombardi RM. Metastatic tumors of the hand. J Hand Surg Am. 1987; 12: 311–316. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/3559096

Libson E, Bloom RA, Husband JE, Stoker DJ. Metastatic tumours of bones of the hand and foot. A comparative review and report of 43 additional cases. Skeletal Radiol. 1987; 16: 387–392. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/3306939

Kasuga I1, Makino S, Kiyokawa H, Katoh H, Ebihara Y, et al. Tumor-related leukocytosis is linked with poor prognosis in patients with lung carcinoma. Cancer. 2001; 92: 2399-2405. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/11745296

Hamilton W, Peters TJ, Round A, Sharp D. What are the clinical features of lung cancer before the diagnosis is made? A population based case-control study. Thorax. 2005; 60: 1059-1065. PubMed: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1747254/

Aoe K1, Hiraki A, Ueoka H, Kiura K, Tabata M, et al. Thrombocytosis as a useful prognostic indicator in patients with lung cancer. Respiration. 2004; 71: 170-173. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/15031573

Dickinson CJ. The aetiology of clubbing and hypertrophic osteoarthropathy. Eur J Clin Invest. 1993; 23: 330-338. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/8344332

Pedersen NT. Occurrence of megakaryocytes in various vessels and their retention in the pulmonary capillaries in man. Scand J Haematol. 1978; 21: 369-375. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/734350

Abe Y, Kurita S, Ohkubo Y, Usui H, Hashizume T, et al. A case of pulmonary adenocarcinoma associated with hypertrophic osteoarthropathy due to vascular endothelial growth factor. Anticancer Res. 2002; 22: 3485-3488. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/12552943

Olán F1, Portela M, Navarro C, Gaxiola M, Silveira LH, et al. Circulating vascular endothelial growth factor concentrations in a case of pulmonary hypertrophic osteoarthropathy. Correlation with disease activity. J Rheumatol. 2004; 31: 614-616. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/14994415

Shannon FJ, Antonescu CR, Athanasian EA. Metastatic thymic carcinoma in a digit: a case report. J Hand Surg Am. 2000; 25: 1169–1172. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/11119681

Ozcanli H, Ozdemir H, Ozenci AM, Söyüncü Y, Aydin AT. Metastatic tumors of the hand in three cases. Acta Orthop Traumatol Turc. 2005; 39: 445–448. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/16531705

Ioia JV, Sumner JM, Gallagher T. Presentation of malignancy by metastasis to the carpal navicular bone. Clin Orthop Relat Res. 1984: 230–233 PubMed: https://www.ncbi.nlm.nih.gov/pubmed/6467720