Abstract

Case Report

Hepatic Pseudolymphoma Mimicking Neoplasia in Primary Biliary Cholangitis: A Case Report

Jeremy Hassoun, Aurélie Bornand, Alexis Ricoeur, Giulia Magini, Nicolas Goossens and Laurent Spahr*

Published: 19 December, 2024 | Volume 8 - Issue 3 | Pages: 152-155

Visualizing a nodule in the liver parenchyma of a patient with chronic liver disease raises the suspicion of hepatic malignancy. We report here the case of a 63-year-old female with primary biliary cholangitis (PBC) in whom a hepatic pseudolymphoma (HPL) was incidentally detected. This fairly rare lesion mimics primary liver cancer, has no specific radiological features, and requires histology for a definite diagnosis. This tumor-like lymphoid liver proliferation has been reported in clinical situations with immune-mediated inflammation including PBC. It can be observed in many organs but very rarely in the liver. The diagnosis of HPL should be considered when detecting a liver nodule in a patient with this particular chronic cholestatic liver disease.

Read Full Article HTML DOI: 10.29328/journal.acr.1001115 Cite this Article Read Full Article PDF

Keywords:

Hepatic malignancy; Chronic liver disease; Chronic cholestatic liver disease; Lymphoid liver proliferation

References

  1. Jones DE, Bassendine MF. Primary biliary cirrhosis. J Intern Med 1997;241:345-8. Available from: https://doi.org/10.1016/s0168-8278(99)80097-x
  2. Wendum D, Boelle PY, Bedossa P, Zafrani ES, Charlotte F, Saint-Paul MC, et al. Primary biliary cirrhosis: proposal for a new simple histological scoring system. Liver Int 2015;35:652-9. Available from: https://doi.org/10.1111/liv.12620
  3. Panjala C, Talwalkar JA, Lindor KD. Risk of lymphoma in primary biliary cirrhosis. Clin Gastroenterol Hepatol 2007;5:761-4. Available from: https://doi.org/10.1016/j.cgh.2007.02.020
  4. Okada T, Mibayashi H, Hasatani K, Hayashi Y, Tsuji S, Kaneko Y, et al. Pseudolymphoma of the liver associated with primary biliary cirrhosis: a case report and review of literature. World J Gastroenterol 2009;15:4587-92. Available from: https://doi.org/10.3748/wjg.15.4587
  5. Jones DE, Metcalf JV, Collier JD, Bassendine MF, James OF. Hepatocellular carcinoma in primary biliary cirrhosis and its impact on outcomes. Hepatology 1997;26:1138-42. Available from: https://doi.org/10.1002/hep.510260508
  6. Schonau JWASJH, H. Risk of cancer and subsequent mortality in primary biliary cholangitis: a population-based cohort study of 3052 patients. Gastro Hep Advances 2023;2:879-888. Available from: https://doi.org/10.1016/j.gastha.2023.05.004
  7. Natarajan Y, Tansel A, Patel P, Emologu K, Shukla R, Qureshi Z, et al. Incidence of Hepatocellular Carcinoma in Primary Biliary Cholangitis: A Systematic Review and Meta-Analysis. Dig Dis Sci 2021;66:2439-2451. Available from: https://doi.org/10.1007/s10620-020-06498-7
  8. Kwon YK, Jha RC, Etesami K, Fishbein TM, Ozdemirli M, Desai CS. Pseudolymphoma (reactive lymphoid hyperplasia) of the liver: A clinical challenge. World J Hepatol 2015;7:2696-702. Available from: https://doi.org/10.4254/wjh.v7.i26.2696
  9. Inoue M, Tanemura M, Yuba T, Miyamoto T, Yamaguchi M, Irei T, et al. A case of hepatic pseudolymphoma in a patient with primary biliary cirrhosis. Clin Case Rep 2019;7:1863-1869. Available from: https://doi.org/10.1002/ccr3.2378
  10. Sim KK, Fernando T, Tarquinio L, Navadgi S. Hepatic reactive lymphoid hyperplasia-associated primary biliary cholangitis masquerading as a neoplastic liver lesion. BMJ Case Rep 2023;16. Available from: https://doi.org/10.1136/bcr-2023-254963
  11. Jiang W, Wu D, Li Q, Liu CH, Zeng Q, Chen E, et al. Clinical features, natural history and outcomes of pseudolymphoma of liver: A case-series and systematic review. Asian J Surg 2023;46:841-849. Available from: https://doi.org/10.1016/j.asjsur.2022.08.113
  12. Fukuo Y, Shibuya T, Fukumura Y, Mizui T, Sai JK, Nagahara A, et al. Reactive lymphoid hyperplasia of the liver associated with primary biliary cirrhosis. Med Sci Monit 2010;16:CS81-6. Available from: https://pubmed.ncbi.nlm.nih.gov/20581780/
  13. Sato S, Masuda T, Oikawa H, Satoh T, Suzuki Y, Takikawa Y, et al. Primary hepatic lymphoma associated with primary biliary cirrhosis. Am J Gastroenterol 1999;94:1669-73. Available from: https://doi.org/10.1111/j.1572-0241.1999.01160.x

Figures:

Figure 1

Figure 1

Figure 1

Figure 2

Similar Articles

Recently Viewed

Read More

Most Viewed

Read More

Help ?