Case Report

Fatal acute necrotizing pancreatitis in a 15 years old boy, is it multisystem inflammatory syndrome in children associated with COVID-19; MIS-C?

Masoumeh Asgarshirazi*, Khadije Daneshjou, Seyed Reza Raeeskarami, Mohammad Reza Keramati and Samrand Fattah Ghazi

Published: 13 January, 2022 | Volume 6 - Issue 1 | Pages: 001-004

Acute pancreatitis in childhood is not common and viral and bacterial infections, bile duct diseases, medications, systemic diseases, trauma, metabolic diseases, and hyperlipidemia are among the most common causes in them. Acute necrotizing pancreatitis is even rarer. 
The clinical presentation of Multisystem Inflammatory Syndrome in Children associated with COVID-19 (MIS-C) includes fever, severe illness, and the involvement of two or more organ systems, in combination with laboratory evidence of inflammation and with or without laboratory or epidemiologic evidence of SARS-CoV-2 infection. We present a case of a 15 years old boy with fatal acute necrotizing pancreatitis that fulfilled MIS-C definition based on RCPCH (Royal College of Pediatrics and Child Health) and CPSP (Canadian Pediatric Surveillance Program) criteria.

Read Full Article HTML DOI: 10.29328/journal.acr.1001056 Cite this Article Read Full Article PDF


Acute necrotizing pancreatitis; MIS-C; COVID-19


  1. Gholami M, Arjmand R. Acute Pancreatitis Caused by COVID-19 in a Child: A Case Report. Int J Enteric Pathog. 2020; 8: 107-109.
  2. Boumitri C, Brown E, Kahaleh Necrotizing Pancreatitis: Current Management and Therapies. Clin Endosc 2017; 50: 357-365.PubMed: https://pubmed.ncbi.nlm.nih.gov/28516758/
  3. Al Mazrouei SS, Saeed GA, Al Helali AA. COVID-19-associated acute pancreatitis: a rare cause of acute abdomen. Radiol Case Rep. 2020; 15: 1601-1603. PubMed: https://pubmed.ncbi.nlm.nih.gov/32685078/
  4. de Madaria E, Capurso G. COVID-19 and acute pancreatitis:examining the causality. Nat Rev Gastroenterol Hepatol. 2021; 18: 3. PubMed: https://pubmed.ncbi.nlm.nih.gov/33203968/
  5. Arbati MM, Molseghi MH. COVID-19 Presenting as AcuteNecrotizing Pancreatitis. J Investig Med High Impact Case Rep. 2021; 9: 1-3. PubMed: https://pubmed.ncbi.nlm.nih.gov/33847153/
  6. Bineshfar N, Mirahmadi A, Karbasian F, Pourbakhtyaran E, Karimi A, et al. Acute Pancreatitis as a Possible Unusual Manifestation of COVID-19 in Children. Case Rep Pediatr. 2021; 6616211. PubMed: https://pubmed.ncbi.nlm.nih.gov/33575053/
  7. Gupta A, Bansal DP, Rijhwani P, Singh V. A Case Report on Acute Pancreatitis in a Patient With Coronavirus Disease 2019 (COVID-19) Pneumonia. Cureus. 2021; 13: e14628. PubMed: https://pubmed.ncbi.nlm.nih.gov/34046267/
  8. Rotar O, Khomiak I, Polanskyy O, Muskovsky Y, Railianu S, et al. Case Report of Fatal Acute Necrotizing Pancreatitis in Patient with COVID-19: We Should Be Aware Of Hemorrhagic Complications. JOP. J Pancreas 2020; 21: 167-171.
  9. Wifi MN, Nabil A, Awad A, Eltatawy R. COVID-induced pancreatitis: case report. Egypt J Inter Med. 2021; 33: 10. PubMed: https://pubmed.ncbi.nlm.nih.gov/33716498/
  10. AlHarmi RAR, Fateel T, Adnan JS, Al Awadhi K. Acute pancreatitis in a patient with COVID-19. BMJ Case Rep. 2021; 14: e239656. PubMed: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7880111/
  11. Nakra NA, Blumberg DA, Herrera-Guerra A, Lakshminrusimha S. Multi-System Inflammatory Syndrome in Children (MIS-C) Following SARS-CoV-2 Infection: Review ofClinical Presentation, Hypothetical Pathogenesis, and Proposed Management. Children. 2020; 7: 69. PubMed: https://pubmed.ncbi.nlm.nih.gov/32630212/
  12. Kiss A, Mac Daragh Ryan P, Mondal T. Management of COVID-19-associated multisystem inflammatory syndrome in children: A comprehensive literature review. Prog Pediat Cardiol. 2021; 63: 101381.PubMed: https://pubmed.ncbi.nlm.nih.gov/33850412/
  13. Bugiantella W, Rondelli F, Boni M, Stella PP, Polistena A, et al. Necrotizing pancreatitis: A review of the interventions. Int J Surg. 2016; 28: S163-eS171. PubMed: https://pubmed.ncbi.nlm.nih.gov/26708848/
  14. Radia T, Williams N, Agrawal P, Harman K, Weale J, et al; Multi-system inflammatory syndrome in children & adolescents (MIS-C): A systematic review of clinical features and presentation. Paediatr Respir Rev. 2021’ 38: 51-57. PubMed: https://pubmed.ncbi.nlm.nih.gov/32891582/


Figure 1

Figure 1

Figure 1

Figure 2

Figure 1

Figure 3

Similar Articles

Recently Viewed

Read More

Most Viewed

Read More

Help ?