Abstract

Case Report

Epiphora as a sign of unexpected underlying squamous cell carcinoma within sinonasal inverted papilloma

Filippo Confalonieri*, Alessandra Di Maria, Raffaele Piscopo, Laura Balia and Luca Malvezzi

Published: 15 June, 2020 | Volume 4 - Issue 1 | Pages: 038-040

Sinonasal inverted papilloma (SIP) is a benign tumor which originates from the sinonasal Schneiderian mucosa and accounts for 0.5% to 4% of all nasal and sinus neoplasm [1]. Pathologically, SIP epithelium inverts into submucosal stroma, which is different from other types of nasal papilloma. Unlike other benign tumors, SIP exhibits remarkable aggressive behaviors, including invasiveness, recurrence and malignant transformation [2]. Therefore, SIP can spread into the paranasal sinus, orbit, and cranial base, which can lead to poor prognosis for SIP patients [2]. Secondary squamous cell carcinoma is malignancy formation within the SIP. It is considered primary if there is no additional mucosal condition or secondary if it occurs in conjunction with an additional condition, which is estimated to occur in about 9% of cases [3]. The authors report the case of a 66-year-old woman with SIP and secondary SCC of the right nasal cavity. This study was adherent with the tenets of the Declaration of Helsinki.

Read Full Article HTML DOI: 10.29328/journal.acr.1001038 Cite this Article Read Full Article PDF

References

  1. Wood JW, Casiano RR. Inverted papillomas and benign nonneoplastic lesions of the nasal cavity. Am J Rhinol Allergy. 2012; 26: 157‐163. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/22487294
  2. Kim DY, Hong SL, Lee CH, Jin HR, Kang JM, et al: Inverted papilloma of the nasal cavity and paranasal sinuses: A Korean multicenter study. Laryngoscope. 2012; 122: 487-494. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/22253070
  3. Nygren A, Kiss K, von Buchwald C, Bilde S. Rate of recurrence and malignant transformation in 88 cases with inverted papilloma between 1998–2008, Acta Oto-Laryngologica. 2016; 136: 3: 333-336. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/26838581
  4. Lisan Q, Laccourreye O, Bonfils P. Sinonasal Inverted Papilloma: From Diagnosis to Treatment Eur Ann Otorhinolaryngol Head Neck Dis. 2016;133: 337-341. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/27053431
  5. Koh J, Walsh P, D'Costa I, Bhatti O. Head and neck squamous cell carcinoma survivorship care. Aust J Gen Pract. 2019; 48: 846‐848. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/31774982
  6. Wild CP, Weiderpass E, Stewart BW, Editor. World Cancer Report: Cancer Research for Cancer Prevention. Lyon, France: International Agency for Research on Cancer. http://publications.iarc.fr/586
  7. Hardy AW, Dwivedi RC, Masterson L, Riffat F, Marker A, et al. Inverted papilloma of lacrimal sac invading into the orbit: Case report and review of literature. J Cancer Res Therapeut. 2015; 11: 238-240.
  8. Hildenbrand T, Weber R, Mertens J, Stuck BA, Hoch S, et al. Surgery of Inverted Papilloma of the Maxillary Sinus via Translacrimal Approach-Long-Term Outcome and Literature Review. J Clin Med. 2019; 8: 1873. PubMed: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6912689/
  9. Xiao-Ting W, Peng L, Xiu-Qing W, Hai-Bo W, Wen-Hui P, et al. Factors affecting recurrence of sinonasal inverted papilloma. Eur Arch Otorhinolaryngol. 2013; 270: 1349–1353. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/23064461
  10. Sbrana MF, Borges RFR, Pinna FR, Neto DB, Voegels RL, et al. Sinonasal inverted papilloma: rate of recurrence and malignant transformation in 44 operated patients. Braz J Otorhinolaryngol. 2019; S1808-8694(19)30088-6. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/31455578

Figures:

Figure 1

Figure 1

Figure 1

Figure 2

Similar Articles

Recently Viewed

Read More

Most Viewed

Read More