Letter to Editor

Achievement of cure following allogeneic HSCT with Flu-Bu regimen in a patient with severe mycosis fungoides and Sezary Syndrome

Mahmut Yeral*

Published: 06 December, 2019 | Volume 3 - Issue 1 | Pages: 054-055

Experience with allogeneic hematopoietic stem cell transplantation (HSCT) in mycosis fungoides/Sezary syndrome (MF/SS) is limited to a small number of case reports and case series [1,2]. The advantage of allogeneic HSCT has been indicated in progressive disease in the review of CIBMTR study groups [3]. A consensus is still not available about the intensity and the content of the conditioning regimen due to the rarity of the disease and heterogeneous patient groups.

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  1. Hosing C, Bassett R, Dabaja B, Talpur R, Alousi A, et al. Allogeneic stem-cell transplantation in patients with cutaneous lymphoma: updated results from a single institution. Ann Oncol. 2015; 26: 2490-2495. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/26416896
  2. Lechowicz MJ, Lazarus HM, Carreras J, Laport GG, Cutler CS, et al. Allogeneic hematopoietic cell transplantation for mycosis fungoides and Sezary syndrome. Bone Marrow Transplant. 2014; 49: 1360-1365. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/25068422
  3. Şanlı H, Akay BN, Saral S, Okçu Heper A, Topçuoğlu P. Unique Presentation of Leukemic Cutaneous CD3/TCR- Phenotype T-Cell Lymphoma with Complete Remission after Allogeneic Stem Cell Transplantation. Turk J Haematol. 2017; 34: 194-195. https://www.ncbi.nlm.nih.gov/pubmed/28008858
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  5. Lechowicz MJ, Lazarus HM, Carreras J, Laport GG, Cutler CS, et al. Allogeneic hematopoietic cell transplantatıon for mycosis fungoides and sezary syndrome. Bone Marrow Transplant. 2014; 49: 1360–1365. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/25068422
  6. Soligo D, Ibatici A, Berti E, Morandi P, Longhi E, et al. Treatment of advanced mycosis fungoides by allogeneic stemcell transplantation with a nonmyeloablative regimen. Bone Marrow Transplant. 2003; 31: 663- 666. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/12692606
  7. Herbert KE1, Spencer A, Grigg A, Ryan G, McCormack C, et al. Graft-versus-lymphoma effect in refractory cutaneous T-cell lymphoma after reduced-intensity HLA-matched sibling allogeneic stem cell transplantation. Bone Marrow Transplant. 2004; 34: 521-525. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/15286686
  8. Duarte RF, Canals C, Onida F, Gabriel IH, Arranz R, et al. Allogeneic hematopoietic cell transplantation for patients with mycosis fungoides and Sézary syndrome: a retrospective analysis of the Lymphoma Working Party of the European Group for Blood and Marrow Transplantation. J Clin Oncol. 2010; 28: 4492–4499. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/20697072
  9. Yang J, Cai Y, Jiang JL, Wan LP, Yan SK, et al. Anti-thymocyte globulin could improve the outcome of allogeneic hematopoietic stem cell transplantation in patients with highly aggressive T-cell tumors. Blood Cancer J. 2015; e332.


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