Abstract

Letter to Editor

Achievement of cure following allogeneic HSCT with Flu-Bu regimen in a patient with severe mycosis fungoides and Sezary Syndrome

Mahmut Yeral*

Published: 06 December, 2019 | Volume 3 - Issue 1 | Pages: 054-055

Experience with allogeneic hematopoietic stem cell transplantation (HSCT) in mycosis fungoides/Sezary syndrome (MF/SS) is limited to a small number of case reports and case series [1,2]. The advantage of allogeneic HSCT has been indicated in progressive disease in the review of CIBMTR study groups [3]. A consensus is still not available about the intensity and the content of the conditioning regimen due to the rarity of the disease and heterogeneous patient groups.

Read Full Article HTML DOI: 10.29328/journal.acr.1001025 Cite this Article Read Full Article PDF

References

  1. Hosing C, Bassett R, Dabaja B, Talpur R, Alousi A, et al. Allogeneic stem-cell transplantation in patients with cutaneous lymphoma: updated results from a single institution. Ann Oncol. 2015; 26: 2490-2495. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/26416896
  2. Lechowicz MJ, Lazarus HM, Carreras J, Laport GG, Cutler CS, et al. Allogeneic hematopoietic cell transplantation for mycosis fungoides and Sezary syndrome. Bone Marrow Transplant. 2014; 49: 1360-1365. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/25068422
  3. Şanlı H, Akay BN, Saral S, Okçu Heper A, Topçuoğlu P. Unique Presentation of Leukemic Cutaneous CD3/TCR- Phenotype T-Cell Lymphoma with Complete Remission after Allogeneic Stem Cell Transplantation. Turk J Haematol. 2017; 34: 194-195. https://www.ncbi.nlm.nih.gov/pubmed/28008858
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  5. Lechowicz MJ, Lazarus HM, Carreras J, Laport GG, Cutler CS, et al. Allogeneic hematopoietic cell transplantatıon for mycosis fungoides and sezary syndrome. Bone Marrow Transplant. 2014; 49: 1360–1365. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/25068422
  6. Soligo D, Ibatici A, Berti E, Morandi P, Longhi E, et al. Treatment of advanced mycosis fungoides by allogeneic stemcell transplantation with a nonmyeloablative regimen. Bone Marrow Transplant. 2003; 31: 663- 666. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/12692606
  7. Herbert KE1, Spencer A, Grigg A, Ryan G, McCormack C, et al. Graft-versus-lymphoma effect in refractory cutaneous T-cell lymphoma after reduced-intensity HLA-matched sibling allogeneic stem cell transplantation. Bone Marrow Transplant. 2004; 34: 521-525. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/15286686
  8. Duarte RF, Canals C, Onida F, Gabriel IH, Arranz R, et al. Allogeneic hematopoietic cell transplantation for patients with mycosis fungoides and Sézary syndrome: a retrospective analysis of the Lymphoma Working Party of the European Group for Blood and Marrow Transplantation. J Clin Oncol. 2010; 28: 4492–4499. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/20697072
  9. Yang J, Cai Y, Jiang JL, Wan LP, Yan SK, et al. Anti-thymocyte globulin could improve the outcome of allogeneic hematopoietic stem cell transplantation in patients with highly aggressive T-cell tumors. Blood Cancer J. 2015; e332.

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